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That drawer knob just doesn’t want to screw in tight to that drawer or cabinet door. What to do? Remove the screw from the knob. Coat the screw hole with a just-dipped nail polish brush, dabbing it just enough so that a thin layer forms. (Depending on how your knob is constructed, you may need to pull the screw out of the actual knob or simply work with the hole in your drawer or cabinet door.) Let the nail polish set for a minute, and then insert the screw and tighten. The bulk provided by the half-dried polish will help the screw tighten better right away…and then the cured polish will help keep it that way.